News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent Headlines

Friday in Sports

Sportscaster Craig Sager battling leukaemia

craig

The longtime sideline reporter is in the fight of his life.

Friday in Sports

This weekend’s sports schedule

blackhawks

A complete look at this weekend's sports schedule.

Friday in Viral Videos

When a brother loses a bet

Dance Bet

A guy loses a bet to his younger brother and must dance on a busy street corner for 30 minutes. What happens next is amazing.

Friday in Trending, Viral Videos

TODAY’S MUST SEE: 50 most frustrating video game moments

Video Games Sonic

Playing video games can be fun, into you run into one of these situations!

Friday in Viral Videos

Fence FAIL

fence

A man who appears intoxicated tries his hardest to climb a fence, but it's not happening.